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Is melatonin harmful for improving sleep? Side effects and benefits
Melatonin can be harmful in certain specific cases. In case of depression, interactions with certain medications and other health conditions, it is advisable to avoid it and always seek the advice of a doctor. That is the reason why.
Table of contents
- What is melatonin and how does it work?
- What does the European regulation say about taking melatonin?
- The effectiveness of melatonin: when it can be useful
- Ineffectiveness and side effects
- Melatonin: Possible drug interactions
What is melatonin and how does it work?
Melatonin is a natural hormone produced by the pineal gland, also known as the epiphysis, in the brain.
Its basic function is to regulate the sleep-wake cycle.
Its functioning depends on light: it is activated in the dark in the evening and gradually decreases in the morning.
When the body produces little melatonin or when there are imbalances in the circadian rhythm, which can lead to difficulty falling asleep or restless sleep, melatonin is usually supplied externally in the form of tablets.
However, its use should be limited to an amount of no more than 1 gram per day, as recommended and regulated by the new European regulation on food supplements.
Exceeding this limit, taking melatonin along with other medications and doing so for a long period of time can actually cause various unwanted side effects.
The effectiveness of melatonin, which acts on sleep receptors, has also been proven for other uses, but certain aspects must be taken into account when taking this hormone.
What does the European regulation on taking melatonin regulate?
Regulation (EU) 432/2012 established a list of food supplements and their conditions of use, including quantities and additional warnings for each substance.
In fact, due to specific contraindications and risks of exceeding the recommended doses, as far as melatonin is concerned:
- "contributes to alleviating the effects of jet lag", with the consumer label indicating that the beneficial effect is obtained by taking at least 0.5 mg of the substance shortly before bedtime on the first day of travel and for a few days after the arrival at the destination is achieved;
- "contributes to reducing the time needed to fall asleep", with the consumer label indicating that the beneficial effect is achieved by taking 1 mg of the substance shortly before bedtime.
The regulation therefore recommends that companies producing melatonin-based food supplements adhere to these quantities and also indicate them on the label, in particular with reference to 1 mg as the recommended daily dose.
Melatonin Effectiveness: When It May Be Useful
In addition to use in insomnia (where studies show greater effectiveness in older people and in certain conditions), effectiveness has also been demonstrated in other cases, such as:
- Prevention of post-operative confusion and restlessness.
- Endometriosis (reducing pain and painkillers).
- For high blood pressure, arrhythmias and jet lag syndrome.
- Migraine â it may have a preventative effect in adults and children, but it is not clear whether it helps treat it.
- Reducing fear of surgery and the amount of sedation needed (in children).
- Using a melamine gel appears to limit sunburn.
- In temporomandibular disorders (disorders affecting the temporomandibular joint and muscles), it could reduce pain in women (if taken 4 weeks before bedtime).
Finally, taking melatonin could improve low platelet counts, which are linked to cancer.
Ineffectiveness and side effects
Taking melatonin alone does not appear to improve sleep disorders due to shift work.
Additionally, it does not reduce symptoms of withdrawal from benzodiazepine-based medications.
It doesn't work for depression and can sometimes even make it worse.
Among the side effects (when taken orally), although it is considered safe for most adults, it is generally recommended to only be used for short periods of time.
The maximum recommended duration of use is two years*.
Possible side effects include: headache, nausea, dizziness and drowsiness; It is important not to operate machinery or drive a car after taking melatonin supplements.
In cases of bleeding disorders, melatonin could worsen symptoms.
Melatonin: Possible drug interactions
The use of melatonin should be moderated or strongly recommended by the doctor in the following cases:
- Taking the contraceptive pill - the latter appears to increase melatonin levels in the body and therefore taking it may worsen side effects;
- Caffeine could also interact with this hormone and increase or decrease its levels in the organism;
- Medications containing fluvoxamine (Luvox) increase the risk of side effects;
- Antidiabetic medications. Here melatonin could lower blood sugar levels too much;
- Immunosuppressants, often used after transplants;
- anticoagulants;
- Nifedipine GITS (Procardia XL), which is used to lower blood pressure;
- sedative medications, as they can increase sleepiness and cause slow breathing;
- Drugs processed by the liver - substrates of cytochrome P450 1A2 (CYP1A2);
- medicines to prevent seizures (anticonvulsants);
- Other risks may occur when melatonin is taken with medications such as warfarin (Coumadin), methamphetamine (Desoxyn), flumazenil (Romazicon).
In certain health conditions and when taking other medications at the same time, it is essential to always seek the advice of a doctor before taking melatonin and to evaluate possible interactions and side effects, bearing in mind that the daily dose regulated by the EU is 1 mg per day .
References:
- https://www.issalute.it/index.php/la-salute-dalla-a-alla-z-menu/m/melatonina
- https://www.webmd.com/vitamins/ai/ingredientmono-940/melatonin
- https://www.nhs.uk/medicines/melatonin
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